Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.

ABSTRACT: Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail.

SUBMITTER: Jahangiri A 

PROVIDER: S-EPMC5571827 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature