MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage.

ABSTRACT:

Background and purpose

Delayed cerebral ischemia (DCI) accounts for a major part of the morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). MicroRNAs (miRNAs) are pathophysiologically involved in acute cerebral ischemia. This study compared miRNA profiles in cerebrospinal fluid from neurologically healthy patients, as well as SAH patients with and without subsequent development of DCI.

Methods

In a prospective case-control study of SAH patients treated with external ventricular drainage and neurologically healthy patients, miRNA profiles in cerebrospinal fluid were screened and validated using 2 different high-throughput real-time quantification polymerase chain reaction techniques. The occurrence of DCI was documented in patient charts and subsequently r

SUBMITTER: Bache S 

PROVIDER: S-EPMC5571886 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature