Patterns of Lymph Node Failure after Dose-escalated Radiotherapy: Implications for Extended Pelvic Lymph Node Coverage.

ABSTRACT:

Background

Clinical trials evaluating the benefit of pelvic radiotherapy (PRT) in the radiotherapeutic management of patients with higher-risk prostate cancer have limited the superior field border to the S1/S2 or L5/S1 interspace. However, imaging and surgical series have demonstrated a high frequency of prostatic lymph node (LN) drainage beyond these landmarks.

Objective

To determine the patterns of radiographically defined abdominopelvic LN failures and their potential implications for PRT field design.

Design, setting, and participants

During 1992-2008, 2694 patients with localized prostate cancer were treated with prostate/seminal vesicle-only radiotherapy without PRT. Some 156 patients had their first failure within the abdominopelvic LNs, of whom 60 had isolate

SUBMITTER: Spratt DE 

PROVIDER: S-EPMC5571898 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature