Docking-based modeling of protein-protein interfaces for extensive structural and functional characterization of missense mutations.

ABSTRACT: Next-generation sequencing (NGS) technologies are providing genomic information for an increasing number of healthy individuals and patient populations. In the context of the large amount of generated genomic data that is being generated, understanding the effect of disease-related mutations at molecular level can contribute to close the gap between genotype and phenotype and thus improve prevention, diagnosis or treatment of a pathological condition. In order to fully characterize the effect of a pathological mutation and have useful information for prediction purposes, it is important first to identify whether the mutation is located at a protein-binding interface, and second to understand the effect on the binding affinity of the affected interaction/s. Computational methods, such as pr

SUBMITTER: Barradas-Bautista D 

PROVIDER: S-EPMC5571915 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature