Response assessment in lymphoma: Concordance between independent central review and local evaluation in a clinical trial setting.

ABSTRACT:

Background

Independent central review of clinical imaging remains the standard for oncology clinical trials with registration potential. A limited independent central review strategy has been proposed for solid tumor trials based on concordance between central and local evaluation of response. Concordance between independent central review and local evaluation of response in hematological malignancies is not known.

Methods

We retrospectively evaluated concordance between prospectively performed central and local assessments of response using the Revised Response Criteria for Malignant Lymphoma across two international, open-label, single-arm, registration studies of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma (N = 102) or systemic anaplastic

SUBMITTER: Gopal AK 

PROVIDER: S-EPMC5572138 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature