The TGF-β signalling negative regulator PICK1 represses prostate cancer metastasis to bone.

ABSTRACT: Backgroud:Constitutive activation of TGF-β signalling is a well-recognised mechanism in bone metastasis of prostate cancer (PCa). Protein Interacting with PRKCA 1 (PICK1) is a critical negative regulator of the TGF-β pathway. However, the clinical significance and biological role of PICK1 in PCa bone metastasis remain obscure.

Methods

PICK1 expression is evaluated by immunohistochemistry (IHC) in 198 PCa patients. Statistical analysis is performed to explore correlation between PICK1 expression and clinicopathological features in PCa patients. The biological role of PICK1 is examined in PC-3 and C4-2B cells in vitro and a mouse intracardial model in vivo.

Results

PICK1 expression is decreased in PCa tissues with bone metastasis and bone-derived cells and downregulation of PIC

SUBMITTER: Dai Y 

PROVIDER: S-EPMC5572169 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature