Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium.

ABSTRACT:

Background

Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.

Methods

We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.

Results

The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer

SUBMITTER: Lophatananon A 

PROVIDER: S-EPMC5572182 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature