Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain.

ABSTRACT:

Objective

Aerobic capacity is the most powerful predictor of all-cause mortality in humans; however, its role in the development of obesity and susceptibility for high-fat diet (HFD)-induced weight gain is not completely understood.

Methods

Herein, a rodent model system of divergent intrinsic aerobic capacity [high capacity running (HCR) and low capacity running (LCR)] was utilized to evaluate the role of aerobic fitness on 1-week HFD-induced (45% and 60% kcal) weight gain. Food/energy intake, body composition analysis, and brown adipose tissue gene expression were assessed as important potential factors involved in modulating HFD-induced weight gain.

Results

HCR rats had reduced 1-week weight gain on both HFDs compared with LCR. Reduced HFD-induced weight gain was as

SUBMITTER: Matthew Morris E 

PROVIDER: S-EPMC5572206 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature