Human Blood CD1c⁺ Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4⁺ T Cells.

ABSTRACT: Dendritic cells (DC) initiate the differentiation of CD4⁺ helper T cells into effector cells including Th1 and Th17 responses that play an important role in inflammation and autoimmune disease pathogenesis. In mice, Th1 and Th17 responses are regulated by different conventional (c) DC subsets, with cDC1 being the main producers of IL-12p70 and inducers of Th1 responses, while cDC2 produce IL-23 to promote Th17 responses. The role that human DC subsets play in memory CD4⁺ T cell activation is not known. This study investigated production of Th1 promoting cytokine IL-12p70, and Th17 promoting cytokines, IL-1β, IL-6, and IL-23, by human blood monocytes, CD1c⁺ DC, CD141⁺ DC, and plasmacytoid DC and examined their ability to induce Th1 and Th17 respon

SUBMITTER: Leal Rojas IM 

PROVIDER: S-EPMC5572390 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature