Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis.

ABSTRACT:

Background

Leishmanolysins have been described as important parasite virulence factors because of their roles in the infection of promastigotes and resistance to host's defenses. Leishmania (Viannia) braziliensis contains several leishmanolysin genes in its genome, especially in chromosome 10. However, the functional impact of such diversity is not understood, but may be attributed partially to the lack of structural data for proteins from this parasite.

Objectives

This works aims to compare leishmanolysin sequences from L. (V.) braziliensis and to understand how the diversity impacts in their structural and dynamic features.

Methods

Leishmanolysin sequences were retrieved from GeneDB. Subsequently, 3D models were built using comparative modeling methods and their dyn

SUBMITTER: Sutter A 

PROVIDER: S-EPMC5572447 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature