Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California.

ABSTRACT:

Background

The incidence of childhood cancers has been increasing and environmental exposure to air toxics has been suggested as a possible risk factor. This study aims to explore ambient exposure to dichloromethane (methylene chloride).

Methods

We frequency matched by birth year approximately 20 cancer-free controls identified from birth records to all childhood cancers ages 0-5 in the California Cancer Registry diagnosed from 1988 to 2012; i.e. 13,636 cases and a total of 270,673 controls. Information on industrial releases of dichloromethane within 3km of birth addresses was retrieved from mandatory industry reports to the EPA's Toxics Release Inventory (TRI). We derived exposure to dichloromethane within close vicinity of birth residences using several modeling technique

SUBMITTER: Park AS 

PROVIDER: S-EPMC5572480 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature