Ventricular enlargement and progressive reduction of cortical gray matter are linked in prodromal youth who develop psychosis.

ABSTRACT: In a recent prospective longitudinal neuroimaging study, clinical high-risk (CHR) individuals who later developed full-blown psychosis showed an accelerated rate of gray matter thinning in superior and medial prefrontal cortex (PFC) and expansion of the ventricular system after applying a stringent correction for multiple comparisons. Although cortical and subcortical volume loss and enlarged ventricles are well characterized structural brain abnormalities among patients with schizophrenia, no prior study has evaluated whether these progressive changes of neuroanatomical indicators are linked in time prior to onset of psychosis. Therefore, we investigated the relationship between the changes in cortical gray matter thickness and ventricular volume using the longitudinal neuroimaging data f

SUBMITTER: Chung Y 

PROVIDER: S-EPMC5572513 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature