Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women.

ABSTRACT:

Unlabelled

In animals, defective brown adipogenesis leads to bone loss. Whether brown adipose tissue (BAT) mass relates to bone mineral density (BMD) in humans is unclear. We determined the relationship between BAT mass and BMD by cold-stimulated positron-emission tomography (PET) and dual-energy X-ray absorptiometry (DXA) in healthy volunteers. Higher BAT mass was associated with higher BMD in healthy women, but not in men, independent of age and body composition.

Introduction

Contrary to the traditional belief that BAT is present only in infants, recent studies revealed significant depots of BAT present in adult humans. In animals, defective brown adipogenesis leads to bone loss. While white adipose tissue mass is a known determinant of BMD in humans, the relationship betw

SUBMITTER: Lee P 

PROVIDER: S-EPMC5572572 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature