Genetic Association Study of KCNQ5 Polymorphisms with High Myopia.

ABSTRACT: Identification of genetic variations related to high myopia may advance our knowledge of the etiopathogenesis of refractive error. This study investigated the role of potassium channel gene (KCNQ5) polymorphisms in high myopia. We performed a case-control study of 1563 unrelated Han Chinese subjects (809 cases of high myopia and 754 emmetropic controls). Five tag single-nucleotide polymorphisms (SNPs) of KCNQ5 were genotyped, and association testing with high myopia was conducted using logistic regression analysis adjusted for sex and age to give P_asym values, and multiple comparisons were corrected by permutation test to give P_emp values. All five noncoding SNPs were associated with high myopia. The SNP rs7744813, previously shown to be as

SUBMITTER: Liao X 

PROVIDER: S-EPMC5572591 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature