Prediction Error Representation in Individuals With Generalized Anxiety Disorder During Passive Avoidance.

ABSTRACT:

Objective

Deficits in reinforcement-based decision making have been reported in generalized anxiety disorder. However, the pathophysiology of these deficits is largely unknown; published studies have mainly examined adolescents, and the integrity of core functional processes underpinning decision making remains undetermined. In particular, it is unclear whether the representation of reinforcement prediction error (PE) (the difference between received and expected reinforcement) is disrupted in generalized anxiety disorder. This study addresses these issues in adults with the disorder.

Method

Forty-six unmedicated individuals with generalized anxiety disorder and 32 healthy comparison subjects group-matched on IQ, gender, and age performed a passive avoidance task while under

SUBMITTER: White SF 

PROVIDER: S-EPMC5572647 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature