Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.

ABSTRACT:

Study design

Systematic literature review.

Objective

To assess the toxicity, common radiation doses, and local control (LC) rates of radiation therapy for chordoma of the spine and sacrum and identify the difference in LC and toxicity between adjuvant, salvage, and primary therapy using radiation.

Summary of background data

Chordoma of the spine is typically a low-grade malignant tumor thought to be relatively radioresistant with a high rate of local recurrence and the potential for metastases. Improved results of modern radiation therapy in the treatment of chordoma support exploration of its role in the management of primary/de novo chordoma or recurrent chordoma.

Methods

We conducted a systematic literature review using PubMed and Embase databases to assess

SUBMITTER: Pennicooke B 

PROVIDER: S-EPMC5572655 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature