Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis.

ABSTRACT: Accumulating evidence suggests that O₃ exposure may contribute to CNS dysfunction. Here, we posit that inflammatory and acute-phase proteins in the circulation increase after O₃ exposure and systemically convey signals of O₃ exposure to the CNS. To model acute O₃ exposure, female Balb/c mice were exposed to 3 ppm O₃ or forced air for 2 h and were studied after 6 or 24 h. Of 23 cytokines and chemokines, only KC/CXCL1 was increased in blood 6 h after O₃ exposure. The acute-phase protein serum amyloid A (A-SAA) was significantly increased by 24 h, whereas C-reactive protein was unchanged. A-SAA in blood correlated with total leukocytes, macrophages, and neutrophils in bronchoalveolar lavage from O₃-exposed mice. A-SA

SUBMITTER: Erickson MA 

PROVIDER: S-EPMC5572691 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature