Retinal cell death dependent reactive proliferative gliosis in the mouse retina.

ABSTRACT: Neurodegeneration is a common starting point of reactive gliosis, which may have beneficial and detrimental consequences. It remains incompletely understood how distinctive pathologies and cell death processes differentially regulate glial responses. Müller glia (MG) in the retina are a prime model: Neurons are regenerated in some species, but in mammals there may be proliferative disorders and scarring. Here, we investigated the relationship between retinal damage and MG proliferation, which are both induced in a reproducible and temporal order in organotypic culture of EGF-treated mouse retina: Hypothermia pretreatment during eye dissection reduced neuronal cell death and MG proliferation; stab wounds increased both. Combined (but not separate) application of defined cell death signaling

SUBMITTER: Sardar Pasha SPB 

PROVIDER: S-EPMC5572737 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature