Sox10⁺ Cells Contribute to Vascular Development in Multiple Organs-Brief Report.

ABSTRACT:

Objective

Previous genetic lineage tracing studies showed that Sox10⁺ cells differentiate into vascular mural cells, limited to neural crest-derived blood vessels in craniofacial tissues, aortic arch, pulmonary arch arteries, brachiocephalic, carotid arteries, and thymus. The purpose of this study was to investigate the contribution of Sox10⁺ cells to the vascular development in other tissues and organs and their relationship with neural crest.

Approach and results

Using genetic lineage tracing technique based on Cre/LoxP system, we examined blood vessels in the adult organs of the mice expressing Sox10-Cre/Rosa-LoxP-red fluorescent protein or Wnt1-Cre/Rosa-LoxP-red fluorescent protein by immunohistological analysis. In addition to previously reported t

SUBMITTER: Wang D 

PROVIDER: S-EPMC5572822 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature