Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants.

ABSTRACT: Background: The pathophysiology of necrotizing enterocolitis (NEC) remains poorly understood.Objective: We assessed the relation between feeding strategies, intestinal microbiota composition, and the development of NEC.Design: We performed a prospective nationwide population-based study, EPIPAGE 2 (Etude Epidémiologique sur les Petits Ages Gestationnels), including preterm infants born at <32 wk of gestation in France in 2011. From individual characteristics observed during the first week of life, we calculated a propensity score for the risk of NEC (Bell's stage 2 or 3) after day 7 of life. We analyzed the relation between neonatal intensive care unit (NICU) strategies concerning the rate of progression of enteral feeding, the direct-breastfeeding policy, and the onse

SUBMITTER: Roze JC 

PROVIDER: S-EPMC5573022 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature