Type 2 diabetes mellitus and biomarkers of neurodegeneration.

ABSTRACT:

Objective

Our objective was to investigate whether type 2 diabetes mellitus (T2DM) influences neurodegeneration in a manner similar to Alzheimer disease (AD), by promoting brain β-amyloid (Aβ) or tau.

Methods

We studied the cross-sectional associations of T2DM with cortical thickness, brain Aβ load, and CSF levels of Aβ and tau in a sample of people from the Alzheimer's Disease Neuroimaging Initiative with diagnoses of AD dementia, mild cognitive impairment, and normal cognition. All (n=816) received MRI, and a subsample underwent brain amyloid imaging (n=102) and CSF Aβ and tau measurements (n=415). Analyses were performed across and within cognitive diagnostic strata.

Results

There were 124 people with T2DM (mean age 75.5 years) and 692 without T2DM (mean age 74.1 y

SUBMITTER: Moran C 

PROVIDER: S-EPMC5573049 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature