Comparison of cognitive and brain grey matter volume profiles between multiple sclerosis and neuromyelitis optica spectrum disorder.

ABSTRACT:

Objective

Brain regions responsible for cognitive dysfunction in MS and neuromyelitis optica spectrum disorder (NMOSD) are not known. Our aim of this study was to investigate whether cognitive function and brain volume differed between MS and NMOSD in Japanese patients.

Methods

Brain MRI and neuropsychological tests including the Wechsler Adult Intelligence Scale-III (WAIS-III), Wechsler Memory Scale-Revised (WMS-R), Trail Making Test (TMT) and Clinical Assessment for Attention (CAT) were performed. Parametric grey matter (GM) and white matter (WM) volumes determined from lesion-filled T1-weighted images using whole-brain voxel-based morphometry (VBM) were compared by two-tailed t test.

Results

Twenty relapsing-remitting MS and sixteen NMOSD patients were included. MS

SUBMITTER: Masuda H 

PROVIDER: S-EPMC5573289 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature