Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype.

ABSTRACT: Cyclooxygenase-2 (COX-2) triggers pro-inflammatory processes that can aggravate neuronal degeneration and functional impairments in many neurological conditions, mainly via producing prostaglandin E2 (PGE₂) that activates four membrane receptors, EP1-EP4. However, which EP receptor is the culprit of COX-2/PGE₂-mediated neuronal inflammation and degeneration remains largely unclear and presumably depends on the insult types and responding components. Herein, we demonstrated that COX-2 was induced and showed nuclear translocation in two neuronal cell lines - mouse Neuro-2a and human SH-SY5Y - after treatment with neurotoxin 6-hydroxydopamine (6-OHDA), leading to the biosynthesis of PGE₂ and upregulation of pro-inflammatory cytokine interleukin-1β. Inhibiting

SUBMITTER: Kang X 

PROVIDER: S-EPMC5573328 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature