A Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress.

ABSTRACT: The molecular mechanisms by which individuals subjected to environmental heat stress either recover or develop heat-related complications are not well understood. We analysed the changes in blood mononuclear gene expression patterns in human volunteers exposed to extreme heat in a sauna (temperature of 75.7 ± 0.86 °C). Our analysis reveals that expression changes occur rapidly with no significant increase in core temperature and continue to amplify one hour after the end of heat stress. The reprogramed transcriptome was predominantly inhibitory, as more than two-thirds of the expressed genes were suppressed. The differentially expressed genes encoded proteins that function in stress-associated pathways; including proteostasis, energy metabolism, cell growth and proliferation, and cell deat

SUBMITTER: Bouchama A 

PROVIDER: S-EPMC5573409 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature