Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases.

ABSTRACT:

Background and purpose

Morin is a natural occurring flavonoid in many dietary plants and has a wide range of beneficial effects on metabolism; however, the mechanism underlying its action remains elusive.

Experimental approach

A reporter assay and the time-resolved FRET assay were used to identify morin as a dual antagonist of liver X receptor (LXR)-α and -β. Morin (100 mg^. 100 g^-1 diet) was administered to high-fat diet-induced obese or LXRβ^-/- mice. The pharmacological effects and mechanism of action of morin were evaluated by Western blot and RT-PCR analyses.

Key results

From the in vitro assays, morin was shown to be a dual antagonist of LXRα and LXRβ. In vivo, morin blunted the development of liver hepatic steatosis, reduced body

SUBMITTER: Gu M 

PROVIDER: S-EPMC5573424 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature