Metabolomic Determinants of Metabolic Risk in Mexican Adolescents.

ABSTRACT:

Objective

The goal of this study was to identify metabolites associated with metabolic risk, separately by sex, in Mexican adolescents.

Methods

Untargeted metabolomic profiling was carried out on fasting serum of 238 youth aged 8 to 14 years, and metabolites associated with a metabolic syndrome risk z-score (MetRisk z-score) were identified separately for boys and girls, using the simulation and extrapolation algorithm. Associations of each metabolite with MetRisk z-score were examined using linear regression models that accounted for maternal education, child's age, and pubertal status.

Results

Of the 938 features identified in metabolomics analysis, 7 named compounds (of 27 identified metabolites) were associated with MetRisk z-score in girls, and 3 named compounds

SUBMITTER: Perng W 

PROVIDER: S-EPMC5573626 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature