Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides.

ABSTRACT: An important goal in the development of polo-like kinase 1 (Plk1) polo-box domain (PBD) binding inhibitors is selectivity for Plk1 relative to Plk2 and Plk3. In our current work we show that Plk1 PBD selectivity can be significantly enhanced by modulating interactions within a previously discovered "cryptic pocket" and a more recently identified proximal "auxiliary pocket."

SUBMITTER: Zhao XZ 

PROVIDER: S-EPMC5573662 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature