Lymphedema evaluation using noninvasive 3T MR lymphangiography.

ABSTRACT:

Purpose

To exploit the long 3.0T relaxation times and low flow velocity of lymphatic fluid to develop a noninvasive 3.0T lymphangiography sequence and evaluate its relevance in patients with lymphedema.

Materials and methods

A 3.0T turbo-spin-echo (TSE) pulse train with long echo time (TE_effective  = 600 msec; shot-duration = 13.2 msec) and TSE-factor (TSE-factor = 90) was developed and signal evolution simulated. The method was evaluated in healthy adults (n = 11) and patients with unilateral breast cancer treatment-related lymphedema (BCRL; n = 25), with a subgroup (n = 5) of BCRL participants scanned before and after manual lymphatic drainage (MLD) therapy. Maximal lymphatic vessel cross-sectional area, signal-to-noise-ratio (SNR), and results from a five-point

SUBMITTER: Crescenzi R 

PROVIDER: S-EPMC5573666 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature