Assessing the effects of subject motion on T₂ relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators.

ABSTRACT:

Purpose

Subject motion may cause errors in estimates of blood T₂ when using the T₂ -relaxation under spin tagging (TRUST) technique on noncompliant subjects like neonates. By incorporating 3D volume navigators (vNavs) into the TRUST pulse sequence, independent measurements of motion during scanning permit evaluation of these errors.

Methods

The effects of integrated vNavs on TRUST-based T₂ estimates were evaluated using simulations and in vivo subject data. Two subjects were scanned with the TRUST+vNav sequence during prescribed movements. Mean motion scores were derived from vNavs and TRUST images, along with a metric of exponential fit quality. Regression analysis was performed between T₂ estimates and mean motion scores. Also, m

SUBMITTER: Stout JN 

PROVIDER: S-EPMC5573669 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature