Ontology highlight
ABSTRACT:
SUBMITTER: Kooreman NG
PROVIDER: S-EPMC5573767 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Cell reports 20170801 8
There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary for maintaining long-term graft persistence. To model this alloimmunity, humanized mice engrafted with human hematopoietic and immune cells could prove to be useful. In this study, an in-depth analysis of graft-infiltrating human lymphocytes and splenocy ...[more]