Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes.

ABSTRACT:

Study design

A prospective genetic association study.

Purpose

The etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degeneration phenotypes have not been evaluated. We studied the prevalence of MCs and genetic association of 41 candidate genes in a large Indian cohort.

Overview of literature

MCs are vertebral endplate signal changes predominantly observed in the lumbar spine. A significant association between MCs and lumbar disc degeneration and nonspecific low back pain has been described, with the etiopathogenesis implicating various mechanical, infective, and biochemical factors.

Methods<

SUBMITTER: Kanna RM 

PROVIDER: S-EPMC5573854 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature