Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers.

ABSTRACT: The glutamate receptor gene, ionotropic N-methyl-D-aspartate 3A (GRIN3A), is one of the seven that code for subunits of N-methyl-D-aspartate receptors, which play an essential role at many synapses in the brain, regulating ion flow across membranes in response to glutamate signaling. In this study, we analyzed 25 single nucleotide polymorphisms (SNPs) within GRIN3A for association with nicotine dependence (ND), which was assessed by smoking quantity, heaviness of smoking index, and the Fagerström test for ND. Both individual SNP and haplotype association tests were performed in African-American (AA) and European-American (EA) samples as well as in the pooled sample consisting of 2,037 individuals from 602 nuclear families. Individual SNP analysis revealed significant associations of 5, 5,

SUBMITTER: Ma JZ 

PROVIDER: S-EPMC5573871 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature