Characterization of ferroptosis in murine models of hemochromatosis.

ABSTRACT: Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death implicated in brain, kidney, and heart pathology. However, the biological roles of iron and iron metabolism in ferroptosis remain poorly understood. Here, we studied the functional role of iron and iron metabolism in the pathogenesis of ferroptosis. We found that ferric citrate potently induces ferroptosis in murine primary hepatocytes and bone marrow-derived macrophages. Next, we screened for ferroptosis in mice fed a high-iron diet and in mouse models of hereditary hemochromatosis with iron overload. We found that ferroptosis occurred in mice fed a high-iron diet and in two knockout mouse lines that develop severe iron overload (Hjv^-/- and Smad4^Alb/Alb mice) but not in a third line t

SUBMITTER: Wang H 

PROVIDER: S-EPMC5573904 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature