Peri-prosthetic tissue cells show osteogenic capacity to differentiate into the osteoblastic lineage.

ABSTRACT: During the process of aseptic loosening of prostheses, particulate wear debris induces a continuous inflammatory-like response resulting in the formation of a layer of fibrous peri-prosthetic tissue at the bone-prosthesis interface. The current treatment for loosening is revision surgery which is associated with a high-morbidity rate, especially in old patients. Therefore, less invasive alternatives are necessary. One approach could be to re-establish osseointegration of the prosthesis by inducing osteoblast differentiation in the peri-prosthetic tissue. Therefore, the aim of this study was to investigate the capacity of peri-prosthetic tissue cells to differentiate into the osteoblast lineage. Cells isolated from peri-prosthetic tissue samples (n = 22)-obtained during revision surgeries-w

SUBMITTER: Schoeman MAE 

PROVIDER: S-EPMC5573935 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature