Dataset Information

Methylated Phenylarsenical Metabolites Discovered in Chicken Liver.

ABSTRACT: We report the discovery of three toxicologically relevant methylated phenylarsenical metabolites in the liver of chickens fed 3-nitro-4-hydroxyphenylarsonic acid (ROX), a feed additive in poultry production that is still in use in several countries. Methyl-3-nitro-4-hydroxyphenylarsonic acid (methyl-ROX), methyl-3-amino-4-hydroxyphenylarsonic acid (methyl-3-AHPAA), and methyl-3-acetamido-4-hydroxyphenylarsonic acid (or methyl-N-acetyl-ROX, methyl-N-AHPAA) were identified in such chicken livers, and the concentration of methyl-ROX was as high as 90 μg kg^-1 , even after a five-day clearance period. The formation of these newly discovered methylated metabolites from reactions involving trivalent phenylarsonous acid substrates, S-adenosylmethionine, and the arsenic (+3 oxidation state) methyltransferase enzyme As3MT suggests that these compounds are formed by addition of a methyl group to a trivalent phenylarsenical substrate in an enzymatic process. The IC₅₀ values of the trivalent phenylarsenical compounds were 300-30 000 times lower than those of the pentavalent phenylarsenicals.

SUBMITTER: Peng H

PROVIDER: S-EPMC5573966 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Methylated Phenylarsenical Metabolites Discovered in Chicken Liver.

Peng Hanyong H Hu Bin B Liu Qingqing Q Li Jinhua J Li Xing-Fang XF Zhang Hongquan H Le X Chris XC

Angewandte Chemie (International ed. in English) 20170504 24

We report the discovery of three toxicologically relevant methylated phenylarsenical metabolites in the liver of chickens fed 3-nitro-4-hydroxyphenylarsonic acid (ROX), a feed additive in poultry production that is still in use in several countries. Methyl-3-nitro-4-hydroxyphenylarsonic acid (methyl-ROX), methyl-3-amino-4-hydroxyphenylarsonic acid (methyl-3-AHPAA), and methyl-3-acetamido-4-hydroxyphenylarsonic acid (or methyl-N-acetyl-ROX, methyl-N-AHPAA) were identified in such chicken livers, ...[more]

PMID: 28470989

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Dataset Information

Methylated Phenylarsenical Metabolites Discovered in Chicken Liver.

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Methylated Phenylarsenical Metabolites Discovered in Chicken Liver.

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