The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia.

ABSTRACT:

Background

Despite increasing data on the impact of the microbiome on cancer, the dynamics and role of the microbiome in infection during therapy for acute myelogenous leukemia (AML) are unknown. Therefore, the authors sought to determine correlations between microbiome composition and infectious outcomes in patients with AML who were receiving induction chemotherapy (IC).

Methods

Buccal and fecal specimens (478 samples) were collected twice weekly from 34 patients with AML who were undergoing IC. Oral and stool microbiomes were characterized by 16S ribosomal RNA V4 sequencing using an Illumina MiSeq system. Microbial diversity and genera composition were associated with clinical outcomes.

Results

Baseline stool α-diversity was significantly lower in patients who deve

SUBMITTER: Galloway-Pena JR 

PROVIDER: S-EPMC5574182 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature