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Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses.

ABSTRACT: Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly increased adrenal mass and plasma corticosterone levels. Microarray analysis found greater than 2-fold changes in expression of 928 genes (P?4-fold and cross-sectional area of fasciculata cells was 2-fold greater. In contrast, genes associated with apoptosis (eg Casp12, Clu,) were downregulated and apoptotic cells (Tunel staining) were fewer (P?

SUBMITTER: Menzies RI 

PROVIDER: S-EPMC5574282 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses.

Menzies Robert I RI   Zhao Xin X   Mullins Linda J LJ   Mullins John J JJ   Cairns Carolynn C   Wrobel Nicola N   Dunbar Donald R DR   Bailey Matthew A MA   Kenyon Christopher J CJ  

Endocrine connections 20170718 7

Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly increased adrenal mass and plasma corticosterone levels. Microarray analysis found greater than 2-fold changes in expression of 928 genes (<i>P</i> < 0.001; 397 up, 531 down). These clustered in pathways involved in signalling, sterol/lipid metabolism,  ...[more]

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