Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis.

ABSTRACT: 11β-Hydroxysteroid dehydrogenase-1 (11β-HSD1) predominantly converts inert glucocorticoids into active forms, thereby contributing to intracellular glucocorticoid levels. 11β-HSD1 is dynamically regulated during inflammation, including in macrophages where it regulates phagocytic capacity. The resolution of inflammation in some disease models including inflammatory arthritis is impaired by 11β-HSD1 deficiency or inhibition. However, 11β-HSD1 deficiency/inhibition also promotes angiogenesis, which is beneficial in mouse models of surgical wound healing, myocardial infarction or obesity. The cell types responsible for the anti-inflammatory and anti-angiogenic roles of 11β-HSD1 have not been characterised. Here, we generated Hsd11b1^MKO mice with LysM-Cre mediat

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC5574305 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature