Genomic analysis of urogenital and rectal <i>Neisseria meningitidis</i> isolates reveals encapsulated hyperinvasive meningococci and coincident multidrug-resistant gonococci.

ABSTRACT:

Objective

Invasive meningococcal disease (IMD) outbreaks in men who have sex with men (MSM) have been associated with meningococcal colonisation of the urethra and rectum, but little is known about this colonisation or co-colonisation with the closely related gonococcus. Whole genome sequencing (WGS) was employed to explore these phenomena.

Methods

Meningococci isolated from the urogenital tract and rectum (n=23) and coincident gonococci (n=14) were analysed by WGS along with contemporary meningococci from IMD (n=11). All isolates were obtained from hospital admissions in Brighton, UK, 2011-2013. Assembled WGS were deposited in the PubMLST/neisseria database (http://pubmlst.org/neisseria) and compared at genomic loci common to gonococci or meningococci.

Results

As exp

SUBMITTER: Harrison OB 

PROVIDER: S-EPMC5574384 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature