Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells.

ABSTRACT: The intestinal epithelium serves critical physiologic functions that are shared among all vertebrates. However, it is unknown how the transcriptional regulatory mechanisms underlying these functions have changed over the course of vertebrate evolution. We generated genome-wide mRNA and accessible chromatin data from adult intestinal epithelial cells (IECs) in zebrafish, stickleback, mouse, and human species to determine if conserved IEC functions are achieved through common transcriptional regulation. We found evidence for substantial common regulation and conservation of gene expression regionally along the length of the intestine from fish to mammals and identified a core set of genes comprising a vertebrate IEC signature. We also identified transcriptional start sites and other putative

SUBMITTER: Lickwar CR 

PROVIDER: S-EPMC5574553 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature