Slowing gait and risk for cognitive impairment: The hippocampus as a shared neural substrate.

ABSTRACT:

Objective

To identify the shared neuroimaging signature of gait slowing and cognitive impairment.

Methods

We assessed a cohort of older adults (n = 175, mean age 73 years, 57% female, 65% white) with repeated measures of gait speed over 14 years, MRI for gray matter volume (GMV) at year 10 or 11, and adjudicated cognitive status at year 14. Gait slowing was calculated by bayesian slopes corrected for intercepts, with higher values indicating faster decline. GMV was normalized to intracranial volume, with lower values indicating greater atrophy for 10 regions of interest (hippocampus, anterior and posterior cingulate, primary and supplementary motor cortices, posterior parietal lobe, middle frontal lobe, caudate, putamen, pallidum). Nonparametric correlations adjusted for dem

SUBMITTER: Rosso AL 

PROVIDER: S-EPMC5574674 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature