Permanent CSF shunting after intraventricular hemorrhage in the CLEAR III trial.

ABSTRACT:

Objective

To study factors associated with permanent CSF diversion and the relationship between shunting and functional outcomes in spontaneous intraventricular hemorrhage (IVH).

Methods

Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III), a randomized, multicenter, double-blind, placebo-controlled trial, was conducted to determine if pragmatically employed external ventricular drainage (EVD) plus intraventricular alteplase improved outcome, in comparison to EVD plus saline. Outcome measures were predictors of shunting and blinded assessment of mortality and modified Rankin Scale at 180 days.

Results

Among the 500 patients with IVH, CSF shunting was performed in 90 (18%) patients at a median of 18 (interquartile range [IQR] 13-30

SUBMITTER: Murthy SB 

PROVIDER: S-EPMC5574677 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature