Odor identification as a biomarker of preclinical AD in older adults at risk.

ABSTRACT:

Objective

To assess odor identification (OI) as an indicator of presymptomatic Alzheimer disease (AD) pathogenesis in cognitively normal aging individuals at increased risk of AD dementia.

Methods

In 274 members of the PREVENT-AD cohort of healthy aging persons with a parental or multiple-sibling history of AD dementia, we assessed the cross-sectional association of OI with potential indicators of presymptomatic AD. Some 101 participants donated CSF, thus enabling assessment of AD pathology with the biomarkers total tau (t-tau), phospho-tau (P₁₈₁-tau), and their ratios with β-amyloid (Aβ_1-42). Adjusted analyses considered age, cognition, APOE ε4 status, education, and sex as covariates. We measured OI using the University of Pennsylvania Smell Id

SUBMITTER: Lafaille-Magnan ME 

PROVIDER: S-EPMC5574678 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature