Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach.

ABSTRACT:

Background

Schizophrenia is a severe mental disorder affecting >21 million people worldwide. Some genetic studies reported that single nucleotide polymorphism (SNP) involving variant rs1344706 from the ZNF804A gene in human beings is associated with the risk of schizophrenia in several populations. Similar results tend to conflict with other reports in literature, indicating that no true significant association exists between rs1344706 and schizophrenia. We seek to determine the level of association of this SNP with schizophrenia in the Asian population using more recent genome-wide association study (GWAS) datasets.

Methods

Applying a computational approach with inclusion of more recent GWAS datasets, we conducted a meta-analysis to examine the level of association o

SUBMITTER: Falola O 

PROVIDER: S-EPMC5574680 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature