Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder which is considered to be the most common cause of dementia. It has a greater impact not only on the learning and memory disturbances but also on social and economy. Currently, there are mainly single-target drugs for AD treatment but the complexity and multiple etiologies of AD make them difficult to obtain desirable therapeutic effects. Therefore, the choice of multi-target drugs will be a potential effective strategy inAD treatment. To find multi-target active ingredients for AD treatment from Selaginella plants, we firstly explored the behaviors effects on AD mice of total extracts (TE) from Selaginella doederleinii on by Morris water maze test and found that TE has a remarkable improvem

SUBMITTER: Deng YH 

PROVIDER: S-EPMC5574911 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature