Interactions of Boron Clusters and their Derivatives with Serum Albumin.

ABSTRACT: Boron clusters are polyhedral boron hydrides with unique properties, and they are becoming increasingly widely used in biology and medicine, including for boron neutron capture therapy (BNCT) of cancers and in the design of novel bioactive molecules and potential drugs. Among boron cluster types, icosahedral boranes, carboranes, and metallacarboranes are particularly interesting, and there is a need for basic studies on their interaction with biologically important molecules, such as proteins. Herein, we report studies on the interaction of selected boron clusters and their derivatives with serum albumin, the most abundant protein in mammalian blood. The interaction of boron clusters with albumin was examined by fluorescence quenching, circular dichroism, dynamic and static light scatterin

SUBMITTER: Goszczynski TM 

PROVIDER: S-EPMC5574927 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature