Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson's disease.

ABSTRACT: Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson's disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the

SUBMITTER: Saenger VM 

PROVIDER: S-EPMC5574998 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature