Lipidomic Signatures of Nonhuman Primates with Radiation-Induced Hematopoietic Syndrome.

ABSTRACT: Concern over potential exposures of ionizing radiation (IR) to large populations has emphasized the need for rapid and reliable methods of biodosimetry to determine absorbed dose and required triage. Lipidomics has emerged as a powerful technique for large-scale lipid identification and quantification. Indirect effects from IR exposure generate reactive oxygen species (ROS) through water hydrolysis and may subsequently damage cellular lipids. Thus, rapid identification of specific affected lipid molecules represents possible targets for biodosimetry. The current study addresses temporal changes in the serum lipidome from 4 h to 28 d in nonhuman primates (NHPs) with radiation-induced hematopoietic syndrome (6.5 Gy exposure, LD_50/30). Statistical analyses revealed a highly dynamic

SUBMITTER: Pannkuk EL 

PROVIDER: S-EPMC5575047 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature