Volumetric Optoacoustic Temperature Mapping in Photothermal Therapy.

ABSTRACT: Photothermal therapy and ablation are commonplace medical procedures employed for treatment of tumors, vascular and brain abnormalities as well as other disorders that require selective destruction of tissues. Yet, accurate mapping of the dynamic temperature field distribution in the treated region represents an unmet clinical need, strongly affecting the clinical outcome of these interventions. We introduce a fast three-dimensional temperature mapping method based on real-time optoacoustic sensing of the treated region coupled with a thermal-diffusion-based model of heat distribution in tissues. Deviations of the optoacoustic temperature readings provided at 40  ms intervals remained below 10% in tissue-mimicking phantom experiments for temperature elevations above 3 °C, as validated by s

SUBMITTER: Landa FJO 

PROVIDER: S-EPMC5575057 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature