Therapeutic effect of human adipose-derived stem cells and their secretome in experimental diabetic pain.

ABSTRACT: Painful neuropathy is one of the complications of diabetes mellitus that adversely affects patients'quality of life. Pharmacological treatments are not fully satisfactory, and novel approaches needed. In a preclinical mouse model of diabetes the effect of both human mesenchymal stromal cells from adipose tissue (hASC) and their conditioned medium (hASC-CM) was evaluated. Diabetes was induced by streptozotocin. After neuropathic hypersensitivity was established, mice were intravenously injected with either 1 × 10⁶ hASC or with CM derived from 2 × 10⁶ hASC. Both hASC and CM (secretome) reversed mechanical, thermal allodynia and thermal hyperalgesia, with a rapid and long lasting effect, maintained up to 12 weeks after treatments. In nerves, dorsal root ganglia and spina

SUBMITTER: Brini AT 

PROVIDER: S-EPMC5575274 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature